Cosmetic compositions having keratolytic and anti-acne activity

A cosmetically acceptable composition with anti-ache or keratolytic activity comprising: 0.01 to 25% by weight of a keratolytic compound complexed to a carrier molecule, 75-99.95 % by weight of a diluent.
Patent number: 5449519
Filing date: Aug 9, 1994
Issue date: Sep 12, 1995
Inventors: Barbara A. Wolf, Florence Snyder
Assignee: Revlon Consumer Products Corporation
Primary Examiner: William E. Bentson, Jr.


What is claimed is:

1. A cosmetically acceptable composition with keratolytic activity comprising:

0.01-75% by weight of a keratolytic compound complexed to a carrier molecule having at least one hydroxyl or amino group, 75-99.9% by weight of a diluent.

2. The composition of claim 1 wherein the keratolytic compound is resorcinol, benzoyl peroxide, salicylic acid, or mixtures thereof.

3. The composition of claim 2 wherein the carrier molecule is hydrolyzed vegetable protein, hydrolyzed animal protein, a branched polyamidoamine, a polyamide, polyaniline, polyurea, polyurethane, polyvinyl alcohol derivative, or mixtures thereof.

4. The composition of claim 3 wherein the carrier molecule is complexed to the keratolytic compound by ionic, covalent, or Van der Waals bonding.

5. The composition of claim 4 wherein the diluent is a cream, lotion, make-up, blush, skin cleanser, sunscreen, toner, astringent, or powder.

6. The composition of claim 4 wherein the complex comprises 10-40% by weight of keratolytic compound and 60-90% by weight of carrier molecule.

7. The composition of claim 6 comprising 0.01-20% by weight of the total composition of the keratolytic ingredient/carrier molecule complex and 80-99.9% by weight of the total composition of diluent.

8. The composition of claim 7 wherein the diluent is a makeup containing 5-70% oil, 10-95% water, and 5-40% pigment.

9. The composition of claim 8 wherein the makeup comprises 0.01-50% silicone, 30-60% water, 0.01-40% pigment and 5-40% oil.

10. The composition of claim 9 wherein the make-up additionally comprises 0.1-20% humectant, 0.1-10% surfactant, and 0.1-5% preservative.

11. A method for treating acne vulgaris comprising:

a) complexing a keratolytic compound to a carrier molecule having at least one hydroxyl or amino group,
b) adding an effective amount of said complex of (a) to a cosmetically acceptable diluent,
c) applying the composition of (b) to a subject's face at least once per day.

12. The method of claim 11 wherein the keratolytic compound is an salicylic acid.

13. The method of claim 12 wherein the diluent is a make-up.

14. The method of claim 13 wherein the carrier molecule is hydrolyzed vegetable protein.

15. The method of claim 14 wherein the salicylic acid is ionically bound to hydrolyzed vegetable protein.

16. The method of claim 15 wherein the make-up comprises 5-70% oil, 1.0-95% water, and 5pigment.

17. The composition of claim 16 wherein the make-up comprises 0.01-50% silicone, 30-60% water, 0.01-40% pigment and 5-40% oil.

18. A facial make-up composition having anti-keratolytic activity comprising:

0.01-50% silicone
0.01-10% of salicylic acid ionically bound to hydrolyzed vegetable protein,
0.01-40% pigment, and
5-40% oil,
wherein when the make-up composition is applied to the face the ionic bond between the salicylic acid and hydrolyzed vegetable protein is ruptured and the tree salicylic acid is absorbed onto the skin.

19. The composition of claim 18 further comprising 0.1-10% surfactant, 0.1-20% humectant, 0.1-30% emollient, or mixtures thereof.

20. The composition of claim 19 wherein the silicone is a mixture of volatile and nonvolatile silicone.