Beautify Me !

Acne is a skin disease that can occur in various stages of life, but is usually perceived as a side effect during puberty. This form of acne called acne vulgaris, and as is most common in parts of the body with skin sebaceous glands such as the face, neck, chest or back. The severity of acne can vary widely, from barely perceived blackheads, known as comedones, to purulent, inflamed pustules and papules (acne papulopustulosa), which can also terminate in abscesses and fistulas. Such a severe form known as acne conglobata.

A cosmetically acceptable composition with anti-ache or keratolytic activity comprising: 0.01 to 25% by weight of a keratolytic compound complexed to a carrier molecule, 75-99.95 % by weight of a diluent.
Patent number: 5449519
Filing date: Aug 9, 1994
Issue date: Sep 12, 1995
Inventors: Barbara A. Wolf, Florence Snyder
Assignee: Revlon Consumer Products Corporation
Primary Examiner: William E. Bentson, Jr.


What is claimed is:

1. A cosmetically acceptable composition with keratolytic activity comprising:

0.01-75% by weight of a keratolytic compound complexed to a carrier molecule having at least one hydroxyl or amino group, 75-99.9% by weight of a diluent.

2. The composition of claim 1 wherein the keratolytic compound is resorcinol, benzoyl peroxide, salicylic acid, or mixtures thereof.

3. The composition of claim 2 wherein the carrier molecule is hydrolyzed vegetable protein, hydrolyzed animal protein, a branched polyamidoamine, a polyamide, polyaniline, polyurea, polyurethane, polyvinyl alcohol derivative, or mixtures thereof.

4. The composition of claim 3 wherein the carrier molecule is complexed to the keratolytic compound by ionic, covalent, or Van der Waals bonding.

5. The composition of claim 4 wherein the diluent is a cream, lotion, make-up, blush, skin cleanser, sunscreen, toner, astringent, or powder.

6. The composition of claim 4 wherein the complex comprises 10-40% by weight of keratolytic compound and 60-90% by weight of carrier molecule.

7. The composition of claim 6 comprising 0.01-20% by weight of the total composition of the keratolytic ingredient/carrier molecule complex and 80-99.9% by weight of the total composition of diluent.

8. The composition of claim 7 wherein the diluent is a makeup containing 5-70% oil, 10-95% water, and 5-40% pigment.

9. The composition of claim 8 wherein the makeup comprises 0.01-50% silicone, 30-60% water, 0.01-40% pigment and 5-40% oil.

10. The composition of claim 9 wherein the make-up additionally comprises 0.1-20% humectant, 0.1-10% surfactant, and 0.1-5% preservative.

11. A method for treating acne vulgaris comprising:

a) complexing a keratolytic compound to a carrier molecule having at least one hydroxyl or amino group,
b) adding an effective amount of said complex of (a) to a cosmetically acceptable diluent,
c) applying the composition of (b) to a subject's face at least once per day.

12. The method of claim 11 wherein the keratolytic compound is an salicylic acid.

13. The method of claim 12 wherein the diluent is a make-up.

14. The method of claim 13 wherein the carrier molecule is hydrolyzed vegetable protein.

15. The method of claim 14 wherein the salicylic acid is ionically bound to hydrolyzed vegetable protein.

16. The method of claim 15 wherein the make-up comprises 5-70% oil, 1.0-95% water, and 5pigment.

17. The composition of claim 16 wherein the make-up comprises 0.01-50% silicone, 30-60% water, 0.01-40% pigment and 5-40% oil.

18. A facial make-up composition having anti-keratolytic activity comprising:

0.01-50% silicone
0.01-10% of salicylic acid ionically bound to hydrolyzed vegetable protein,
0.01-40% pigment, and
5-40% oil,
wherein when the make-up composition is applied to the face the ionic bond between the salicylic acid and hydrolyzed vegetable protein is ruptured and the tree salicylic acid is absorbed onto the skin.

19. The composition of claim 18 further comprising 0.1-10% surfactant, 0.1-20% humectant, 0.1-30% emollient, or mixtures thereof.

20. The composition of claim 19 wherein the silicone is a mixture of volatile and nonvolatile silicone.

An acne treatment gel composition, effective at low concentrations of tretinoin, is provided for topical application. The composition is highly effective in treating acne conditions and is capable of being stored without refrigeration for long periods of time without losing therapeutic effectiveness and while maintaining the uniformity and stability of the gel.
Patent number: 4247547
Filing date: Mar 19, 1979
Issue date: Jan 27, 1981
Inventor: Alan M. Marks
Assignee: Johnson & Johnson


What is claimed is:

1. A gel formulation for topical application comprising from about 0.01% to about 0.025% by weight of said formulation of tretinoin; and a vehicle system consisting essentially of (a) from about 84 to about 99% by weight of said formulation of an organic solvent selected from the group consisting of ethanol, isopropanol, and propylene glycol; (b) an effective amount to inhibit oxidation of said tretinoin of a pharmaceutically acceptable antioxidant soluble in said organic solvent; and (c) an effective amount to cause gelling of hydroxypropyl cellulose.

2. The product of claim 1 wherein the antioxidant is selected from the group consisting of butylated hydroxyanisole, butylated hydroxytoluene, .alpha.-tocopherol, ascorbic acid, and propyl gallate.

3. The product of claim 2 which contains from about 0.01 to about 0.10% by weight of said antioxidant and from about 0.5 to about 5.0% by weight of said hydroxypropyl cellulose.

4. The product of claim 1 wherein said organic solvent comprises a mixture selected from the group consisting of ethanol and propylene glycol; isopropanol and proplyene glycol; and ethanol and isopropanol.

5. The product of claim 1 further comprising a dye.

6. The product of claim 1 further comprising a perfume oil.

7. The product of claim 1 further comprising a sunscreen.

8. The product of claim 1 further comprising an antimicrobial.

9. The product of claim 1 further comprising a topical corticosteroid.

10. A gel formulation for topical treatment of acne vulgaris consisting essentially of:

from about 0.01 to about 0.025% by weight of tretinoin;
from about 84 to about 99% by weight of an organic solvent selected from the group consisting of ethanol, isopropanol, propylene glycol and mixtures thereof;
from about 0.025 to about 0.075% by weight of an antioxidant selected from the group consisting of butylated hydroytoluene, butylated hydroxyanisole, ascorbic acid, propyl gallate, and .alpha.-tocopherol;
and from about 0.5 to about 3.0% of hydroxypropyl cellulose.

Novel pharmaceutical compositions containing 1:1 zinc methionine complex salts having the formula:
Patent number: 4039681
Filing date: Feb 23, 1976
Issue date: Aug 2, 1977
Inventor: Mahmoud M. Abdel-Monem
Assignee: Zinpro Corporation


What is claimed is:

1. A composition for treating acne comprising a pharmaceutically acceptable carrier and a small but pharmaceutically effective acne alleviating amount of a 1:1 zinc methionine complexed salt of the formula:

[CH.sub.3 SCH.sub.2 CH.sub.2 CH(NH.sub.2)COO.Zn.sup.+.sup.+].sub.w X

wherein X is a non-toxic anion which has no inhibiting effect on the therapeutic effectiveness of said 1:1 zinc methionine complex, and W is an integer equal to the anionic charge of X.

2. The composition of claim 1 wherein said anion is an inorganic anion.

3. The composition of claim 2 wherein said compound is 1:1 zinc methionine acid sulfate.

4. The composition of claim 2 wherein said composition is in dosage form, with each dosage containing from about 50 milligrams to about 1500 milligrams of said 1:1 zinc methionine complex.

5. The composition of claim 4 wherein the dosage form of said 1:1 zinc methionine complex contains from about 100 milligrams to about 250 milligrams.

6. The composition of claim 4 wherein said carrier is an orally administrable liquid pharmaceutical carrier.

7. The composition of claim 4 wherein said carrier is an orally administrable water soluble solid pharmaceutical carrier.

8. A method of treating acne in a patient in need thereof which comprises orally administering to said patient a unit dosage of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a small but pharmaceutically effective acne alleviating amount of a 1:1 zinc methionine complex having the formula:

[CH.sub.3 SCH.sub.2 CH.sub.2 CH(NH.sub.2)COO.Zn.sup.+.sup.+].sub.w X

wherein X is a non-toxic inorganic anion inert to the pharmaceutical activity of the 1:1 zinc methionine complex and W is an integer equal to the anionic charge of X.

9. The method of claim 8 wherein said 1:1 zinc methionine complex is zinc methionine acid sulfate.

10. The method of claim 8 wherein said 1:1 zinc methionine complex is zinc methionine chloride.

This invention relates to an improved method and composition for controlling all grades of acne vulgaris using a combination of sodium in the form of a pharmacologically acceptable sodium salt and an acne controlling compound selected from the group consisting of methyclothiazide, polythiazide and trichlormethazide, which is therapeutically effective in increasing sodium excretion in the sebaceous gland thereby controlling acne vulgaris eruptions. The conjoint use of the sodium salt and the acne controlling compound significantly reduces the unwanted side effects caused by the administration of the acne controlling compound including nausea, dizziness, hypotension and diuresis, which are experienced in some patients when the acne controlling compound is employed in acne treatment absent the conjoint use of the sodium salt.
Patent number: 4443442
Filing date: Dec 21, 1979
Issue date: Apr 17, 1984
Inventor: Scott D. Skillern



What is claimed is:

1. A method for the treatment of acne vulgaris in a human having acne vulgaris which comprises conjointly administering an acne controlling compound induced side effect reducing amount comprising at least 0.2 grams of sodium in a form of a pharmacologically acceptable sodium salt and a therapeutically effective amount of an acne controlling compound selected from the group consisting of polythiazide and trichlormethiazide.

2. A method for the treatment of acne vulgaris in a human having acne vulgaris which comprises conjointly administering on a bi-daily basis an acne controlling compound induced side effect reducing amount comprising at least 0.2 grams of sodium in the form of a pharmacologically acceptable sodium salt and a therapeutically effective amount of an acne controlling compound selected from the group consisting of polythiazide and trichlormethiazide.

3. A pharmacological dose unit which is useful in the treatment of acne vulgaris in a human having acne vulgaris comprising in combination 0.2 grams to 0.8 grams of sodium in the form of a pharmacologically acceptable sodium salt and a therapeutically effective amount of an acne controlling compound selected from the group consisting of polythiazide and trichlormethiazide.

4. A pharmacological dose unit, as defined in claim 3, wherein the acne controlling compound is polythiazide in an amount of 0.5 to 5.0 mg.

5. A pharmacological dose unit, as defined in claim 3, wherein the acne controlling compound is trichlormethiazide in an amount from 0.5 to 5.0 mg.

Vitamins for Acne - Will It Work?
Acne is the most common skin diseases. A lot of people all over the world have experienced some form of acne at some point of their lives; some have experienced more acne and some less. The reasons for the appearance of acne can be: genetic, environmental, hormonal imbalance, and others.

Lack of zinc, vitamin C, vitamin B, vitamin A, and other vitamins and minerals may lead to acne.
Since the cause of acne is natural and effected by the body’s hormonal imbalance, the person who suffers from acne should check the individual reason for his / her acne and take care of the problem naturally.
There are many more causes of acne that should be treated along with vitamin consumption. Some of the causes are: smoking, sweat, dirt, excess testosterone, metabolism, genes, nutrition, and more.

Some of these causes can be treated by simply changing the person’s basic life style and taking care of oneself.
Supplements can help the body to get its balance back.

The supplements can be vitamins and mineral:
Vitamin C: essential for collagen formation, a protein that helps the skin to build connective tissues and is also anti-inflammatory.
Vitamin B: Helps to produce new body cells and improves the neural functioning.
Vitamin A: essential for the body’s hormonal balance and effects the skins health.
Zinc: Helps to better absorb vitamin A, essential for the body’s immunity system, anti-inflammatory, and also helps to keep hormonal balance.

There are many more vitamins and minerals which can be used in order to treat acne. The way to deal with it is to check what the body is missing in order to keep its balance.

It is very important to notice that excess of vitamins can sometimes become toxic, and can also hurt the person who consumes it, can cause stomachaches and other bad symptoms, therefore the best advice would be to go to the doctor and check the body’s hormonal balance and get his opinion.